milestone Next-generation Communication Network next-generation communication system description Artificial Intelligence artificial intelligence description Deep Learning deep learning description Deep Reinforcement Learning deep reinforcement learning description Multi-Agent System multi-agent system description scenario Mobile Edge Computing mobile edge computing description Integrated Sensing and Communication integrated sensing and communication description framework Multi-Agent Deep Reinforcement Learning To optimize key factors of communication systems in decentralized manner, we propose multi-agent deep reinforcement learning framework. Single-Agent Deep Reinforcement Learning To optimize key factors of communication systems in centralized manner, we propose single-agent deep reinforcement learning framework.